Experiment 1174808
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | ZAHARKO,DS: GRIESHABER,CK: PLOWMAN,J: CRADOCK,JC:. (1986). THERAPEUTIC AND PHARMACOKINETIC RELATIONSHIPS OF FLAVONE ACETIC ACID: AN AGENT WITH ACTIVITY AGAINST SOLID TUMORS.. 70(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOGS WERE ABLE TO SUSTAIN HIGH PLASMA LEVELS OF 700 UG/ML OF THIS DRUG FOR UP TO 14 HOURS WITHOUT TOXIC SIDE EFFECTS. HOWEVER, PLASMA LEVELS OF 200 UG/ML FOR 56 HOURS CAUSED TOXIC SIGNS OF SEDATION, GASTROINTESTINAL DISTRESS AND TRANSIENT PERIPHERAL NEUROPATHY. SUSTAINED PLASMA CONCENTRATIONS OF 430 UG/ML ALSO RESULTED IN TOXICITY AFTER 28 HOURS OF INFUSION. |
| Dose amount | VAR |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | DOG |
| Dose expression | DOSE |