Experiment 1175126
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | KALLA,NR: ROVAM,E: RANGA,A: BAHTIA,S: FRICK,J:. (1986). INVOLVEMENT OF PROSTAGLANDIN IN THE ANTIFERTILITY EFFECTS OF GOSSYPOL.. 34(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | RATS WERE DOSED WITH EITHER GOSSYPOL,GOSSYPOL AND PROSTAGLANDIN F2 ALPHA,OR GOSSYPOL AND THE PROSTAGLANDIN SYNTHESIS INHIBITOR,ASPIRIN IN ORDER TO DETERMINE THE ROLE OF PROSTAGLANDINS IN GOSSYPOL'S ACTIVITY.ANIMALS WERE DOSED FOR 4 WEEKS. SPERM MOTILITY IN GOSSYPOL TREATED ANIMALS WAS MARKEDLY DECREASED WHEREAS THE PROSTAGLANDIN AND GOSSYPOL GROUP HAD COMPLETE INHIBITION OF MOTILITY. SPERM OF THE PROSTAGLANDIN/GOSSYPOL GROUP WERE DECAPITATED IN ALL ANIMALS. THIS WAS NOT OBSERVED WITH GOSSYPOL ALONE. THOSE TREATED WITH GOSSYPOL AND ASPIRIN DEMONSTRATED DECREASED SPERM MOTILITY BUT NO DECAPITATION PHENOMENOM. IN THE GOSSYPOL/ASPIRIN GROUP,LESS PRONOUNCED HISTOLOGICAL CHANGES WERE OBSERVED IN THE TESTES COMPARED TO THE GOSSYPOL GROUP. LIKEWISE, THE PROSTAGLANDIN/GOSSYPOL GROUP SHOWED MORE PRONOUNCED HISTOLOGICAL CHANGES IN THE TESTES AS COMPARED TO THE GOSSYPOL GROUP. |
| Dose amount | 40.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |