Experiment 1175201

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeIN RATION
OrganismEmpty organism
CitationSHAWLEY,RV: ROLF JR,LL:. (1984). EXPERIMENTAL CANTHARIDIASIS IN THE HORSE.. 45(11)
Amount utilized
Compound isolated
DiseaseIN THIS STUDY 8 HORSES WERE GIVEN 450-489 UG/KG & 2 HORSES WERE GIVEN 720 UG/KG OF CATHARIDIN. BOTH THE HORSES IN THE HIGH DOSE GROUP, & 1 HORSE IN THE LOWER DOSE GROUP DIED.FINDINGS INCLUDE INCREASED CARDIAC RATE, RESPIRATORY RATE & RECTAL TEMP. THERE WERE DECREASES IN TOTAL CALCIUM.MAGNESIUM & POTASSIUM.SURVIVING HORSES HAD LOWER ARTERIAL OXYGEN TENSION,TOTAL PROTEIN,SERUM CREATININE KINASE,ARTERIAL CO2,& PLASMA BICARBONATE LEVELS AT ONE OR MORE OCCASIONS. ANOREXIA & DEPRESSION WERE COMMON.SEVERE EROSIONS OF THE GINGIVA & ORAL MUCOSA WERE ALSO PRESENT.OTHER CLINICAL SIGNS INCLUDE: WACHING THE MUSXXLE IN WATER: STIFF SHORT-STRIDED GAIT: AND SYNCHRONOUS DIAPHARAGMATIC FLUTTER.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHORSE
Dose expressionDOSE