Experiment 1175349

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationMAROUN,JA: MAKSYMIUK,A: EISENHAUER,E: STEWART,DJ: YOUNG,V: PATER,J:. (1986). PHASE II STUDY OF ACIVICIN IN NON-SMALL CELL LUNG CANCER: A NATIONAL CANCER INSTITUTE OF CANADA STUDY.. 70(11)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE II STUDY, 36 PATIENTS WITH PREVIOUSLY UNTREATED NON-SMALL CELL LUNG CANCER WERE TREATED. STARTING DOSE WAS 15 MG/SQ.M. FOR 5 DAYS REPEATED EVERY 21 DAYS. OF 33 EVALUABLE PATIENTS THERE WERE 2 PARTIAL REMISSIONS AND 7 MINOR RESPONSES. HEMATOLOGICAL TOXICITY WAS DOSE RELATED WITH ONE DEATH DUE TO NEUTROPENIC SEPSIS AT 18 MG/SQ.M. GASTROINTESTINAL TOXICITY WAS THE MOST PREVILANT NON-HEMATOLOGICAL TOXICITY. NEUROLOGICAL SYMPTOMS WERE SEEN IN 48% OF THE PATIENTS.
Dose amount15-18 MG
Number1
Qualitative resultEQUIVOCAL
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE