Experiment 1175632
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | ANON:. (1986). INVESTIGATION OF THE ADDITIVE POTENTIAL OF TENIPOSIDE AND VINCRISTINE IN NON-HODGKIN'S LYMPHOMA.. 70(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS COMPARATIVE STUDY OF DIFFERENT DRUG COMBINATIONS FOR THE TREATMENT OF NON-HODGKIN'S LYMPHOMA, 64 PATIENTS WERE TREATED WITH A COMBINATION OF DOXORUBICIN, CYCLOPHOSPHAMIDE, VINCRISTINE, AND PREDNISOLONE. 56% OF THE PATIENTS HAD STAGE IV ADVANCED DISEASE. 51% OF THE PATIENTS HAD RECEIVED NO PREVIOUS TREATMENT. PATIENTS RECEIVED AT LEAST 3 COURSES OF THERAPY, EACH COURSE WAS REPEATED AT 3 WEEK INTERVALS. 44% OF THE PATIENTS ACHIEVED COMPLETE REMISSIONS, AND RELAPSE FREE SURVIVAL OF OVER 5 YEARS WAS ESTIMATED AT 38%. GRADE 3 MYELOSUPPRESSION WAS SEEN IN 8% OF THE PATIENTS, AND GRADE 1 NEUROTOXICITY IN 52% OF THE PATIENTS. MORE SEVERE NEUROTOXICITY WAS SEEN IN 8% OF THE PATIENTS. |
| Dose amount | 1.4 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |