Experiment 1175633
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | ANON:. (1986). INVESTIGATION OF THE ADDITIVE POTENTIAL OF TENIPOSIDE AND VINCRISTINE IN NON-HODGKIN'S LYMPHOMA.. 70(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS COMPARATIVE STUDY OF DIFFERENT DRUG COMBINATIONS FOR THE TREATMENT OF NON-HODGKIN'S LYMPHOMA, 119 PATIENTS WERE TREATED WITH A COMBINATION OF DOXORUBICIN, CYCLOPHOSPHAMIDE, TENIPOSIDE, VINCRISTINE, AND PREDNISOLONE. 55% OF THE PATIENTS HAD STAGE IV ADVANCED DISEASE AND 68% HAD NO PREVIOUS TREATMENT. PATIENTS WERE GIVEN AT LEAST 3 COURSE OF THERAPY, COURSES WERE REPEATED AT 3 WEEK INTERVALS. 47% OF THE PATIENTS ACHIEVED COMPLETE REMISSION. RELAPSE FREE SURVIVAL OF OVER 5 YEARS WAS ESTIMATED TO BE 45%. GRADE 3 MYELOSUPPRESSION WAS SEEN IN 27% OF THE PATIENTS, AND GRADE 1 NEUROTOXICITY WAS SEEN IN 42%. MORE MARKED NEUROTOXICITY WAS SEEN IN 20% OF THE PATIENTS. |
| Dose amount | 1.4 MG |
| Number | 2 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |