Experiment 1175637
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | SAVARAJ,N: LU,K: DIMERY,I: FEUN,LG: BURGESS,M: KEATING,M: LOO,TL:. (1986). CLINICAL PHARMACOLOGY OF HOMOHARRINGTONINE.. 70(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL PHARMACOKINETICS WAS STUDIED IN 8 CANCER PATIENTS. THE DRUG WAS ADMINISTERED BY CONTINUOUS 6 HOUR INFUSION. THE ALPHA AND BETA HALF LIVES OF UNCHANGED DRUG IN THE PLASMA WAS 0.5 H AND 9.3 H RESP. TOTAL CLEARANCE WAS 177.4 ML/H/KG. THE APPARENT VOLUME OF DISTRIBUTION WAS 2.4 L/KG. THE TOTAL DRUG EQUIVALANT DISAPPEARED FROM THE PLASMA IN A TRIPHASIC MANNER, WITH A TERMINAL HALF LIFE OF 67.5 H, A TOTAL CLEARANCE OF 30.9 ML/H/KG AND A VOLUME OF DISTRIBUTION OF 2.7 L/KG. THE TOTAL 72 H URINARY EXCRETION OF TRITIUM WAS 28.2% OF THE ADMINISTERED DOSE, 38.3% OF WHICH WAS UNCHANGED DRUG. |
| Dose amount | 3-4 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |