Experiment 1175639

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationCHARNEY,DS: HENINGER,GR: STERNBERG,DE:. (1982). ASSESSMENT OF ALPHA-2 ADRENERGIC AUTORECEPTOR FUNCTION IN HUMANS: EFFECTS OF ORAL YOHIMBINE.. 30(23)
Amount utilized
Compound isolated
DiseaseYOHIMBINE WAS ADMINISTERED TO DETERMINE ALPHA-2 ADRENERGIC AUTORECEPTOR FUNCTIONS IN HUMANS. PLASMA FREE 3-METHOXY-4-HYDROXYPHENYLETHYLENEGLYCOL LEVELS WERE SIGNIFICANTLY INCREASED. MINOR INCREASES IN BLOOD PRESSURE WERE SEEN IN 15 AND 20 MG. GROUPS. THESE HIGHER DOSE GROUPS ALSO EXHIBITED OTHER AUTONOMIC SYMPTOMS INCLUDING PILOERECTION AND RHINORRHEA. BEHAVIORAL EFFECTS, SUCH AS ANXIETY, WERE NOT NOTED.
Dose amount10-20 MG
Number2
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitPERSON
Dose expressionDOSE