Experiment 1177807
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Senecio douglasii (ASTERACEAE) |
| Citation | JOHNSON,AE: MOLYNEUX,RJ:. (1984). TOXICITY OF THREADLEAF GROUNDSEL (SENECIO DOUGLASII VAR LONGILOBUS) TO CATTLE.. 45(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOSE EXPRESSED AS MG OF PYRROLIZIDINE ALKALOID IN THE PLANT PER KG OF CALF BODY WEIGHT. ANIMALS WERE DOSED FOR 15 TO 20 DAYS. TOXIC EFFECTS AND HIGH MORTALITY WERE GENERALLY SEEN IN CALVES FED 10 MG/KG/DAY OR MORE. SIGNS OF SENECIO TOXICOSIS (ROUGHENED COAT,DRY SCALY NOSE,DIARRHEA,STARING FACES,STAGGERING WALK & DROOPING HEAD) WERE NOTED. GROSS PATHOLOGICAL EXAMINATION REVEALED VARIABLE LIVER CHANGES INCLUDING HEMORRHAGE,FIBROSIS, DISCOLORATION,ICTERUS & EDEMA. SERUM AST AND GGT LEVELS WERE ELEVATED. HISTOPATHOLOGIC EXAMINATION REVEALED PRINCIPLE LESIONS IN THE LIVER. |
| Dose amount | 5.40 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CALF |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | POWDER |