Experiment 1177808

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismSenecio douglasii (ASTERACEAE)
CitationJOHNSON,AE: MOLYNEUX,RJ:. (1984). TOXICITY OF THREADLEAF GROUNDSEL (SENECIO DOUGLASII VAR LONGILOBUS) TO CATTLE.. 45(1)
Amount utilized
Compound isolated
DiseaseDOSE EXPRESSED AS MG OF PYRROLIZIDINE ALKALOID IN THE PLANT PER KG OF CALF BODY WEIGHT. CALVES WERE DOSED FOR 15 TO 20 DAYS,& 2 DAYS AT HIGHEST DOSE LEVEL. SERUM AST AND GGT WERE ELEVATED. GROSS PATHOLOGICAL EXAMINATION REVEALED VARIABLE LIVER CHANGES INCLUDING HEMORRHAGE,FIBROSIS,DISCOLORATION,ICTERUS AND EDEMA. HISTOPATHOLOGICAL STUDIES SHOWED THAT PRINCIPLE LESIONS OCCURRED IN THE LIVER.
Dose amount10.40 MG
Number2
Qualitative resultACTIVE
AnimalCALF
Per unitKG
Dose expressionDOSE
ExtractPOWDER