Experiment 1177976
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | NEUMAN,J: DE ENGEL,AMF: NEUMAN,MP:. (1986). PILOT STUDY OF THE EFFECT OF RAUBASINE ON PLATELET BIOLOGICAL ACTIVITY.. 36(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS STUDY,14 PATIENTS WITH CONDITIONS THAT SUGGEST INCREASE PLATELET AGGREGATION WERE GIVEN A DAILY ORAL DOSE OF THE DRUG FOR 6 WKS. PATIENT CONDITIONS INCLUDE CORONARY HEART DISEASE,OBLITERATIVE ARTEROSCLEROSIS OF LOWER LIMBS,& HYPERTENSION. THERE WAS A REDUCTION IN PLATELET AGREGATION IN 12 PATIENTS,& NON SIGNIFICANT REDUCTIONS IN PLASMA FIBRINOGEN & PLATELET FACTOR 3. NO VARIATIONS WERE SEEN IN BLEEDING TIME,PLATELET COUNT,PLATELET ADHESION,OR PLASMA LIPIDS,GLUCOSE & UREA. HEMATOLOGICAL EXAMINATION REVEALED A 10% REDUCTION IN RED BLOOD CELLS & HEMATORCRIT IN 5 OF 14 PATIENTS. THERE WERE NO CHANGES IN WHITE BLOOD CELL COUNTS. NO CHANGES WERE OBSERVED IN CLINICAL,ECG & FUNDUS EXAMINATIONS. |
| Dose amount | 60.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |