Experiment 1179941

Details

PropertyValue
Pharmacology
Administration routeIN RATION
OrganismCurcuma longa (ZINGIBERACEAE)
CitationBILLE,N: LARSEN,JC: HANSEN,EV: WURTZEN,G:. (1985). SUBCHRONIC ORAL TOXICITY OF TURMERIC OLEORESIN IN PIGS.. 23(11)
Amount utilized
Compound isolated
DiseaseANIMALS WERE FED DIETARY LEVELS OF THIS OLEORESIN EQUAL TO 60, 296, AND 1551 MG/KG/DAY FOR 102-109 DAYS. ALL DOSE LEVELS SHOWED A SIGNIFICANT DOSE-DEPENDENT INCREASE IN LIVER AND THYROID WEIGHT. A REDUCTION IN WEIGHT GAIN AND FEED CONVERSION EFFICIENCY WAS OBSERVED IN THE HIGH DOSE GROUP. THE TWO HIGHER DOSE GROUPS SHOWED EVIDENCE OF THYROIDAL HYPERPLASIA, EPITHELIAL CHANGES IN THE URINARY BLADDER AND KIDNEY, AND PERICHOLANGITIS.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalPIG
Dose expressionDOSE
ExtractOLEORESIN