Experiment 1183934
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | LETENDRE,L: LUDWIG,J: PERRAULT,J: SMITHSON,WA: KOVACH,JS:. (1984). HEPATOCELLULAR TOXICITY DURING THE TREATMENT OF REFRACTORY ACUTE LEUKEMIA WITH INDICINE N-OXIDE.. 54() |
| Amount utilized | |
| Compound isolated | |
| Disease | TWENTY-TWO PATIENTS WITH REFRACTORY ACUTE LEUKEMIA RECEIVED DAILY DOSES OF THE TITLE COMPOUND FOR 5 CONSECUTIVE DAYS IN A DOSE-SEEKING STUDY. OF EIGHT PATIENTS WITH REFRACTORY ACUTE LYMPHOCYTIC LEUKEMIA, ONE HAD A COMPLETE REMISSION AND ONE HADA PARTIAL REMISSION. OF 11 PATIENTS WITH REFRACTORY ACUTE NONLYMPHOCYTIC LEUKEMIA, 2 PATIENTS HAD COMPLETE REMISSIONS. OF THREE PATIENTS WITH BLAST CRISIS OF CHRONIC GRANULOCYTIC LEUKEMIA, ONE PATIENT HAD A PARTIAL REMISSION. FIVE PATIENTS HAD SEVERE HEPATIC TOXICITY, PROBABLY DUE TO VENOCCLUSIVE DISEASE INDUCED BY THE DRUG. WHETHER HEPATOTOXICITY AND ANTILEUKEMIC ACTIVITY ARE A RESULT OF THE SAME MECHANISM OF ACTION BY THE TITLE DRUG IS NOT KNOWN. |
| Dose amount | 3.0 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |