Experiment 1183936
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | LETENDRE,L: SMITHSON,WA: GILCHRIST,GS: BURGERT,EO: HOAGLAND,CH: AMES,MM: POWIS,G: KOVACH,JS:. (1981). ACTIVITY OF INDICINE N-OXIDE IN REFRACTORY ACUTE LEUKEMIA.. 47() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TITLE COMPOUND WAS STUDIED IN TEN CANCER PATIENTS: FOUR CHILDREN AND TWO ADOLESCENTS WITH REFRACTORY ACUTE LYMPHOCYTIC LEUKEMIA AND FOUR ADULTS WITH REFRACTORY ACUTE NONLYMPHOCYTIC LEUKEMIA (THREE ACUTE MYELOCYTIC, ONE MYELOMONOCYTIC). TWO PATIENTS, A FOUR YEAR OLD BOY WITH ACUTE LYMPHOCYTIC LEUKEMIA AND A 22 YEAR OLD MAN WITH ACUTE MYELOCYTIC LEUKEMIA, ACHIEVED COMPLETE REMISSION LASTING 3 AND 5+ MONTHS, RESPECTIVELY. ANOTHER 15 YEAR OLD MALE WITH ACUTE LYMPHOCYTIC LEUKEMIA HAD A PARTIAL REMISSION FOR 4 MONTHS. TOXICITIES INCLUDED BONE MARROW SUPPRESSION, MILD ANOREXIA AND NAUSEA AND TRANSIENT ELEVATION OF LIVER ENZYMES. JAUNDICE AND LIVER FAILURE, PRESUMABLY INDUCED BY THE DRUG, OCCURRED IN TWO PATIENTS. |
| Dose amount | 3.0 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |