Experiment 1189431
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | OOTHMAN,MA: ABOU-DONIA,MB:. (1987). PHARMACOKINETICS AND BIOAVAILABILITY OF GOSSYPOL IN MALE RATS.. 7(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | SINGLE OR 14 DAILY DOSES IN CORN OIL WERE ADMINISTERED.MEAN ORAL BIOAVAILABILITY WAS 11.7%.THE CHANGE IN PLASMA GOSSYPOL CONCENTRATION AFTER A SINGLE OR MULTIPLE DOSING SHOWED A BIPHASIC PATTERN. A SINGLE ORAL DOSE WAS ELIMINATED 5 TIMES FASTER THAN THE DAILY ADMINISTERED COMPOUND. A SINGLE ORAL DOSE HAD A HALF-LIFE OF 16.6 HRS. THE TOTAL PLASMA CLEARANCE VOLUMES FOLLOWING A SINGLE DOSE WERE AS FOLLOWS: 0.14 L/HR/KG, 3.3 L/KG AND 73.01 MG.HR/L, RESPECTIVELY. ON THE OTHER HAND, 14 DAILY CONSECUTIVE ORAL DOSES HAD A HALF-LIFE OF 80.1 HR. |
| Dose amount | 10.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAM(CASTRATE) |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |