Experiment 1189673
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | COUTINHO,EM: MELO,JF:. (1988). CLINICAL EXPRIENCE WITH GOSSYPOL IN NON-CHINESE MEN. A FOLLOW-UP.. 37(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL WAS ADMINISTERED TO 12 BRAZILIAN VOLUNTEERS AGES 25-40 DAILY FOR 4 MONTHS.THE DOSE WAS THEN REDUCED TO 60 MG WEEKLY (20 MG 3 TIMES PER WK).THIS DOSE WAS MAINTAINED FOR 6-8 MONTHS. A SIGNIFICANT REDUCTION IN SPERM MOTILITY WAS DETECTED IN ALL SUBJECTS.AN INCREASE IN THE NUMBER OF IMMATURE CELLS IN THE EJACULATE WAS ALSO DETECTED IN ALL SUBJECTS.SEVERE OLIGOSPERMIA OR AZOOSPERMIA DEVELOPED IN ALL SUBJECTS. 2 YEARS FOLLOWING DISCONTINUATION,3 MEN WERE STILL AZOOSPERMIC. ONLY 1 MAN WHO WAS AZOOSPERMIC 2 YEARS AFTER DISCONTINUATION HAD A LATE (3 YEARS) RECOVERY. 2 OF THE 3 MEN WHO WERE SUBJECTED TO HIGH SPERMATIC VEIN LIGATION BECAUSE OF VARICOCELE REMAINED AZOOSPERMIC 2 YRS AFTER THE OPERATION.THE THIRD PATIENT,WHO DID NOT HAVE THE OPERATION,ALSO REMAINED AZOOSPERMIC. OF THE 9 PATIENTS WHO RECOVERED,3 HAVE FATHERED CHILDREN DURING THE LAST 2 YRS. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |