Experiment 1189676
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | XU,D: CAI,WJ: ZHU,BH: DONG,CJ: ZHENG,ZC: GAO,ZQ:. (1988). CLINICAL SAFETY OF LING-TERM ADMINISTRATION OF GOSSYPOL IN 32 CASES.. 37(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY INCLUDED 32 CHINESE MALES WHO HAD TAKEN GOSSYPOL FOR 6-12 YRS.THE DOSE OF THE LOADING PHASE WAS 20 MG/DAY & WHEN THE SPERM COUNT WAS BELOW 4/ML,THE MAINTENANCE DOSE WAS 40 MG/WK. THIS DOSAGE WAS EFFECTIVE & NO SERIOUS SIDE EFFECTS WERE SEEN AFTER 1 YR.IN 15 CASES OF STOPPING DRUG INTAKE FOR 6-12 MONTHS,12 OF THE 15 CASES RECOVERED TO MORE THAN 4 ML,3(TAKING THE DRUG FOR 7-8 YRS)HAD NOT RECOVERED. THE SPGT OF 4 CASES DURING DRUG INTAKE INCREASED AT 1ST AND AFTER 1-2 YRS RECOVERED GRADUALLY.AS FOR PLASMA K DETERMINATION,A DESCENDING TREND WAS FOUND AFTER TAKING THE DRUG FOR 3-6 MOS AND IT RECOVERED GRADUALLY 1 YEAR AFTER DRUG INTAKE. THE K CONCENTRATION TENDED TO STABILIZE AFTER 2 YRS BUT EVEN AFTER 6 YRS OF DRUG INTAKE THE AVERAGE PLASMA K WAS STILL LOWER THAN THE VALUE BEFORE DRUG INTAKE.HOWEVER,NO HYPOKALEMIC SYMPTOMS WERE OBSERVED. PLASMA TESTOSTERONE LEVELS WERE NORMAL.SEXUAL FUNCTION WAS NORMAL. THERE WAS A STATISTICAL LOWERING OF IMMUNE FUNCTION (T LYMPHOCYTES AND OTHER PARAMETERS WERE MEASURED). |
| Dose amount | 20.0 MG |
| Number | 3 |
| Qualitative result | WEAK ACTIVITY |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |