Experiment 1201503
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | MENG,CD: ZHU,JC: CHEN,ZW: WONG,LT: ZHANG,GY: HU,YZ: DING,JH: WANG,XL: QIAN,SZ: WANG,C: MANCHIN,D: PINOL,A: WAITES,GMH:. (1988). RECOVERY OF SPERM PRODUCTION FOLLOWING THE CESSATION OF GOSSYPOL TREATMENT: A TWO-CENTRE STUDY IN CHINA.. 11(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | OF 46 MEN WHO HAD TAKEN GOSSYPOL, 28 RETURNED TO A DEFINED RECOVERY LEVEL OF SPERMATOGENIC FUNCTION IN 1.9 YRS. FAILURE TO RECOVER ASSOCIATED WITH LONGER TREATMENT, GREATER DOSES OF GOSSYPOL, SMALLER TESTICULAR VOLUME & HIGHER SERUM FSH LEVELS. NO PRETREATMENT DATA ARE AVAILABLE, SO GOSSYPOL DAMAGE TO NORMAL STRUCTURES CANNOT BE DISTINGUISHED FROM AGGRAVATION OF PRE-EXISTING ABNORMALITIES. ACTION OF GOSSYPOL APPEARS TO BE AT THE TESTICULAR LEVEL, RESULTING IN IMPAIRED SPERMATOGENESIS AND IMPAIRED SERTOLI CELL FUNCTION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | MALE |