Experiment 1210541

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismHeliotropium europaeum (BORAGINACEAE)
CitationSEAMAN,JT:. (1987). PYRROLIZIDINE ALKALOID POISONING OF SHEEP IN NEW SOUTH WALES.. 64(6)
Amount utilized
Compound isolated
DiseaseSAID TO BE A CAUSE OF PYRROLIZIDINE ALKALOID TOXICITY IN SHEEP. NECROPSY REPORTS INDICATE SHRUNKEN, FIBROTIC LIVERS AND INCREASED FLUID IN BODY CAVITITIES. LIVERS SHOW CHRONIC ATROPIC HEPATOPHY, CELL LOSS AND BILE DUCTULE HYPERPLASIA. LIPID ACCUMULATION AND OTHER DEGENERATIVE CHANGES WERE ALSO NOTED. SHEEP SHOWED WEIGHT LOSS AND EMACIATION. DEATH OCCURRED OVER SEVERAL WEEKS. ALKALOID POISONING MAY PREDISPOSE SHEEP TO HEPATOGENOUS CHRONIC COPPER TOXICITY.
Number1
Qualitative resultACTIVE
AnimalSHEEP
Dose expressionDOSE
ExtractPLANT