Experiment 1215706

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationSHARP,DS: BENOWITZ,NL:. (1990). PHARMACOEPIDEMIOLOGY OF THE EFFECT OF CAFFEINE ON BLOOD PRESSURE.. 47(1)
Amount utilized
Compound isolated
DiseaseTHE EFFECT OF CAFFEINE ON THE BLOOD PRESSURE OF HABITUAL VS. INFREQUENT CAFFEINE USERS WAS COMPARED BY REGRESSION ANALYSIS. AT SERUM CAFFEINE LEVELS OF 0.0 NG/ML NO DIFFERENCE WAS FOUND. AT SERUM CAFFEINE LEVELS OF 3000 NG/ML, BLOOD PRESSURE WAS SIGNIFICANTLY HIGHER IN INFREQUENT USERS, AS THE HABITUAL USERS HAD DEVELOPED A TOLERANCE TO CAFFEINE'S HYPERTENSIVE EFFECTS. THE DIFFERENCE WAS 5.3 MM-HG SYSTOLIC AND 3.6 MM-HG DIASTOLIC, LARGE ENOUGH TO EXAGGERATE PREVALENCE OF HYPERTENSION IN CROSS-SECTIONAL SURVEYS THAT FAIL TO ASSESS BOTH PROXIMATE CAFFEINE CONSUMPTION AND USUAL CAFFEINE USE BY PARTICIPANTS.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE