Experiment 1216876
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | YU,DY:. (1983). CLINICAL OBSERVATION OF 144 CASES OF RHEUMATOID ARTHRITIS TREATED WITH GLYCOSIDE OF RADIX TRIPTERYGIUM WILFORDII.. 3(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | SATISFACTORY RESULTS OBTAINED IN TREATMENT OF 144 CASES OF RHEUMATOID ARTHRITIS WITH A "GLYCOSIDIC FRACTION" OF THE TITLE PLANT. TOTAL EFFECTIVE RATE WAS 93.3%. THIS INCLUDED CLINICAL REMISSIONS(17.6%), EFFECTIVE(37.5%) AND IMPROVEMENT(38.2%). COURSE OF TREATMENT WAS THREE MONTHS AT A DOSAGE OF 1-1.5 MG/KG. SIDE EFFECTS INCLUDED MILD GASTROINTESTINAL DISTURBANCES AND AMENORRHEA IN FEMALE PATIENTS AND GYNECOMASTIA IN MALES. THESE REACTIONS SUBSIDED AFTER WITHDRAWAL OF THE DRUG. CLINICAL AND LABORATORY OBSERVATION OF THE ACTION OF THIS DRUG SUGGESTED SUPPRESSION OF CELLULAR AND HUMORAL IMMUNITY. |
| Dose amount | 1-1.5 MG |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |
| Gender | GIVEN TO BOTH SEXES |