Experiment 1218983

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismGlycyrrhiza glabra (FABACEAE)
CitationTERASAWA,K: BANDOH,M: TOSA,H: HIRATE,J:. (1986). DISPOSITION OF GLYCYRRHETIC ACID AND ITS GLYCOSIDES IN HEALTHY SUBJECTS AND PATIENTS WITH PSEUDOALDOSTERONISM.. 9()
Amount utilized
Compound isolated
Disease5 NORMAL SUBJECTS GIVEN G.GLABRA DECOCTION. MAXIMUM SERUM CONCENTRATIONS OF GLYCYRRHETIC GLYCOSIDES WERE REACHED 4 HRS POST INGESTION + WERE ELIMINATED WITHIN 72 HRS. GLYCYRRHETIC ACID REACHED MAXIMUM SERUM CONCENTRATION 24 HR POST INGESTION. HIGHEST CONCENTRATION WAS 30 NG/ML, AND EXCRETION WAS NOT COMPLETE AFTER 96 HRS IN 2 SUBJECTS. IN 2 CASES OF CLINICAL PSEUDOALDOSTERONISM THE SERUM GLYCYRRHETIC ACID LEVELS WERE AS HIGH AS 70-80 NG/ML WHILE GLYCOSIDES WERE QUITE LOW.
Dose amount5%
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionCONC USED
ExtractDECOCTION