Experiment 1219050
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Malvaviscus conzattii (MALVACEAE) |
| Citation | BHARGAVA,SK:. (1990). ANTI-SPERMATOGENIC ACTIVITY OF MALVIDIN CHLORIDE IN LANGUR MONKEYS (PRESBYTIS ENTELLUS ENTELLUS DUFRESNE).. 13(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | MALVIDIN CHLORIDE WAS USED IN THE TESTS. DAILY FEEDING FOR 60 DAYS WAS CARRIED OUT. INHIBITION OF SPERMATOGENESIS RESULTED. THE WEIGHTS OF TESTES AND EPIDIDYMIDES WERE REDUCED AND THERE WAS ATROPHY OF THE LEYDIG CELLS. IN THE EPIDIDYMIDES, EPITHELIAL CELL HEIGHTS WERE REDUCED AFTER TREATMENT. CONSPICUOUS SHRINKAGE OF SEMINIFEROUS TUBULES AND LEYDIG CELL NUCLEI WAS EVIDENT. DEPLETION OF TOTAL PROTEINS, RNA, SIALIC ACID, ALKALINE/ACID PHOSPHATASE ACTIVITY IN TESTES AND EPIDIDYLIDES WITH THE ELEVATION OF TESTICULAR LEVELS OF CHOLESTEROL AND GLYCOGEN ALSO OCCURRED. BLOOD/SERUM ANALYSIS AND HEMATOLOGY OF MALVIDIN CHLORIDE TREATED MONKEYS REVEALED THAT ALL OF THE CLINICALLY IMPORTANT PARAMETERS WERE WELL WITHIN THE NORMAL RANGE. THE SLIGHTLY INCREASED BILIRUBIN CONCENTRATION AND ALKALINE PHOSPHATASE ACTIVITY RETURNED TO NORMAL RANGE WITHIN 30 DAYS AFTER THE LAST DOSE. |
| Dose amount | 50.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(PRESBYTIS) |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |