Experiment 1221393

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationKAPLAN,MM: ALLING,DW: ZIMMERMAN,HJ: WOLFE,HJ: SEPERSKY,RA: HIRSCH,GS: ELTA,GH: GLICK,KA: EAGEN,KA:. (1986). A PROSPECTIVE TRIAL OF COLCHICINE FOR PRIMARY BILILARY CIRRHOSIS.. 315(23)
Amount utilized
Compound isolated
Disease60 PATIENTS WITH PRIMARY BILIARY CIRRHOSIS IN RANDOMIZED, DOUBLE BLIND STUDY TO DETERMINE EFFECTIVENESS OF GIVEN COMPOUND. 2 X DAILY DOSE GIVEN FOR 2 YRS IMPROVED SERUM ALBUMIN, BILIRUBIN, ALKALINE PHOSPHATASE, CHOLESTEROL & AMINOTRANSFERASES. THERE WAS NO IMPROVEMENT IN SEVERITY OF SMYPTOMS OR HISTOLOGIC FINDINGS. AFTER 4 YEARS, CUMULATIVE MORTALITY WAS 47% AMONG THOSE GIVEN PLACEBO, 21% AMONG THOSE GIVEN COMPOUND. DIARRHEA WAS AN INFREQUENT SIDE EFFECT.
Dose amount0.6 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitPERSON
Dose expressionDOSE