Experiment 1223793
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | BORZIEIX,MG: CAHN,J:. (1987). EXPERIMENTAL APPROACH OF TREATMENT OF CEREBAL ISCHEMIA BY A COMBINATION OF RAUBASINE AND ALMITRINE.. 37(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS SUBJECTED TO 1 HR LIGATION OF BOTH COMMON CAROTID ARTERIES AND HYPOTENSION INDUCED BY S.C. NITROPRUSSIDE. FROM 1 HR AFTER THIS UNTIL SACRIFICE THEY WERE DOSED TWICE DAILY WITH GIVEN CHEMICAL(1/3) IN COMBINATION WITH ALMITRINE(2/3). THIS RESULTED IN IMPROVEMENT IN VISUAL PLACING RESPONSE, INCREASE IN LEARNING(EVIDENCED BY ABILITY TO REMEMBER PASSIVE AVOIDANCE REFLEX), INCREASED K+ CONTENT & DECREASED CA++ AND WATER CONTENT OF CEREBRUM VS.UNTREATED, WHEN RX CONTINUED 3 DAYS. OVER 4 WEEKS, RX RESULTED IN DECREASED FREE FATTY ACID LEVELS AND LESSENED ENCEPHALOMALACIA VS.CONTROLS. |
| Dose amount | 16.7 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |