Experiment 1225693
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Andrographis paniculata (ACANTHACEAE) |
| Citation | AKBARSHA,MA: MANIVANNAN,B: HAMID,KS: VIJAYAN,B:. (1990). ANTIFERTILITY EFFECT OF ANDROGRAPHIS PANICULATA (NEES) IN MALE ALBINO RAT.. 28(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY FEEDING OF THE PLANT MATERIAL FOR 60 DAYS RESULTED IN CESSATION OF SPERMATOGENESIS, DEGENERATIVE CHANGES IN THE SEMINIFEROUS TUBULES, AND REGRESSION OF LEYDIG CELLS. ALSO SEEN: REGRESSIVE AND/OR DEGENERATIVE CHANGES IN THE EPIDIDIMUS, SEMINAL VESICLES, VENTRAL PROSTATE AND COAGULATING GLAND. THERE WAS REDUCTION IN THE WEIGHT AND FLUID CONTENT OF THE ACCESSORY GLANDS. THE TREATMENT ALSO RESULTED IN ACCUMULATION OF GLYCOGEN AND CHOLESTEROL IN TESTIS AND VENTRAL PROSTATE. THE RESULTS SUGGEST ANTISPERMATOGENIC AND ANTIANDROGENIC ACTIVITY IN THE EXTRACT. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | LEAVES |
| Gender | MALE |