Experiment 1226023

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationWESTRA,P: VAN THIEL,MJS: VERMEER,GA: SOETERBROEK,AM: SCAF,AHJ: CLASSSENS,HA:. (1986). PHARMACOKINETICS OF GALANTHAMINE (A LONG-ACTING ANTICHOLINESTERASE DRUG) IN ANESTHETIZED PATIENTS.. 58(11)
Amount utilized
Compound isolated
DiseaseSERUM CONCENTRATION FOLLOWED A BIEXPONENTIAL DECAY, WITH A HALF-LIFE OF 6.42-2.15 MIN BETWEEN 2 AND 30 MIN AFTER DOSING, AND A SUBSENQUENT HALF-LIFE OF 264 MIN. TOTAL CLEARANCE WAS 5.37 ML/MIN/KG, RENAL CLEARANCE 1.36 ML/MIN/KG. CUMULATIVE URINARY EXCRETION BETWEEN 0 AND 48 HOURS AFTER DOSING WAS 28% OF DOSE; BILIARY EXCRETION DURING 24 HOURS WAS 0.2% OF DOSE. THERE WAS NO EVIDENCE OF GLUCURONIDE OR SULFATE CONJUGATION.
Dose amount0.3 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitKG
Dose expressionDOSE