Experiment 1226207
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Senecio longilobus (ASTERACEAE) |
| Citation | HUXTABLE,RJ:. (1979). NEW ASPECTS OF THE TOXICOLOGY AND PHARMACOLOGY OF PYRROLIZIDINE ALKALOIDS.. 10() |
| Amount utilized | |
| Compound isolated | |
| Disease | SINGLE DOSE WILL LEAD TO DOUBLING OF RIGHT VENTRICLE TO BODY WEIGHT RATIO WITHIN 7 DAYS. ANATOMIC CHANGES NOTED IN PULMONARY ARTERIAL ENDOTHELIUM WERE INCREASED PERMEABILITY, THROMBI FORMATION AND ENDOTHELIAL PROLIFERATION. THESE CHANGES WERE PREVENTED BY ADMINISTRATION OF P450 INHIBITORS SKF525A AND METYRAPONE IMPLYING IT IS METABOLITE WHICH HAS PULMONOTOXIC EFFECT. |
| Dose amount | 60.0 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | PLANT |