Experiment 1226346
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Azadirachta indica (MELIACEAE) |
| Citation | PRAKASH,AO: MISHRA,A: METHA,H: MATHUR,R:. (1991). EFFECT OF ETHANOLIC EXTRACT OF AZADIRACHTA INDICA SEEDS ON ORGANS IN FEMALE RATS.. 62(2) |
| Amount utilized | |
| Compound isolated | |
| Disease |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|
| Dose amount | 0.1 ML |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | ETOH(90%)EXT |
| Gender | FEMALE |