Experiment 1226676
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | ZHANG,YG: HUANG,GZ: WANG,HJ: WU,ZB: XING,SL:. (1984). AN EXPERIMENTAL PATHOLOGICAL STUDY OF ACUTE LEI GONG TENG (TRIPTERYGIUM WILFORDII HOOK) INTOXICATION IN RATS.. 4(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | ACUTE POSIONING WAS INDUCED IN RATS BY SINGLE AND REPEATED EXPOSURES TO THE DECOCTION OF THE ROOTBARK OF THE TITLE PLANTS. PATHOLOGICAL CHANGES IN THE VITAL ORGANS WERE STUDIED BY LIGHT AND ELECTRON MICROSCOPY AND HISTOCHEMICALLY. THE RELATIVELY SPECIFIC AND CONSISTENT PATHOLOGICAL CHANGES FOLLOWING POSIONING WERE OBSERVED IN THE LYMPHOID ORGANS. VARYING DEGREES OF DEGENERATION AND NECROSIS IN THE PARENCHYMATOUS CELLS EXISTED IN THE HEART, LIVER AND KIDNEY. THE MECHANISM OF TOXICOLOGICAL/PATHOLOGICAL CHANGES AND THE RELATION BETWEEN CLINICAL AND PATHOLOGICAL CHANGES WERE APPROACHED AND IT WAS POSTULATED THAT THE DECOCTION POSSESSES CYTOTOXIC ACTION WHICH IS ANALOGOUS TO THAT OF AN IMMUNOSUPPRESSIVE AGENT. |
| Dose amount | 13.3 GM |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ETOAC EXT |
| Gender | GIVEN TO BOTH SEXES |