Experiment 1226680
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | PU,LX: ZHANG,TM:. (1990). EFFECTS OF TRIPTOLIDE ON T LYMPHOCYTE FUNCTIONS IN MICE.. 11(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | LYMPHOCYTE PROLIFERATION INDUCED BY CONCANAVALIN A OR LIPOPOLYSACCHARIDE WAS SUPPRESSED BY TRIPTOLIDE AT 50 AND 500 NG/ML. AT 5 NG/ML THE SUPPRESSIVE EFFECT ON LYMPHOCYTE PROLIFERATION INDUCED BY CON A WAS MUCH STRONGER THAN THAT INDUCED BY LIPOPOLYSACCHARIDE. THE HUMORAL IMMUNE REACTION MONITORED BY QUANTITATIVE HEMOLYSIS SPECTROPHOTOMETRY WAS SUPPRESSED BY TRIPTOLIDE AT 0.75 AND 1 MG/KG IP. INTERLEUKIN 2 PRODUCTION BY MOUSE SPLEEN CELLS WAS SUPPRESSED BY TRIPTOLIDE AT 5,50 AND 500 NG/ML IN VITRO AND AT 0.5, 0.75 AND 1 MG/KG IP IN VIVO. T CELLS INDUCED BY SUPRAOPTIMAL IMMUNE STIMULI WERE SUPPRESSED BY TRIPTOLIDE AT 0.5 AND 0.75 MG/KG, IP. THUS, T SUBPOPULATIONS AND B LYMPHOCYTES MAY BE TARGET CELLS OF TRIPTOLIDE. |
| Dose amount | 0.5 MG |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |