Experiment 1227023
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | WANG,ZF: ZHANG,YG: HUANG,GZ:. (1991). AN EXPERIMENTAL PATHOLIGIC STUDY OF SUBCHRONIC TOXICITY OF ETHYL ACETATE EXTRACT OF TRIPTERYGIUM WILFORDII.. 20(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | SUBCHRONIC TOXICITY WAS INDUCED IN RATS BY EXPOSURE TO THE EXTRACT FOR SIX MONTHS. AT THE END OF THE EXPERIMENT, PATHOLOGIC CHANGES IN THE MAIN ORGANS WERE STUDIED BY LIGHT AND ELECTRON MICROSCOPY. ACID-NAPHTHYL ACETATE ESTERASE(ANAE) TECHNIQUE WAS ALSO USED FOR IDENTIFYING THE RATIO CHANGES BETWEEN T AND B LYMPHOCYTES IN LYMPHOID ORGANS. THE NUMBER OF LYMPHOCYTES DECREASED IN LYMPHOID ORGANS, ESPECIALLY IN B LYMPHOCYTE DISTRIBUTION AREAS. OBVIOUS DEGENERATION AND NECROSIS WAS NOT FOUND IN LYMPHOID ORGANS, BUT THE RATIO OF T/B LYMPHOCYTES INCREASED. IN LOWEST DOSAGE GROUP, SERIOUS PATHOLOGIC CHANGES OF SPERMATOGENIC CELLS WERE OBSERVED. HOWEVER, NO PATHOLOGIC CHANGES IN THE HEART, LIVER, KIDNEYS, ETC. WERE SEEN. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Extract | ETOAC EXT |
| Gender | MALE |