Experiment 1227029
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | LU,QX: CHEN,XM: LIU,P: CHENG,K: SHEN,XM: WANG,BJ: XUE,SP:. (1990). COMPARATIVE STUDIES ON ANTIFERTILITY MECHANISM AND TOXICOLOGY OF TRIPTERYGIUM WILFORDII MONOMER T4 AND GOSSYPOL.. 12(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | INHIBITION OF SPERMATOGENESIS + TURNOVER OF BASIC NUCLEAR PROTEIN IN LATE ELONGATED SPERMATIDS (RAT TESTIS) BY TRIPCHLOROLIDE(T4) WAS MORE OBVIOUS THAN THAT BY GOSSYPOL. CLUSTERED POSITIVE DEPOSITS OF T-GT FOUND IN INNER EDGES OF EPIDIDYMAL EPITHELIUM. HEAD + TAIL SEPARATION, MID-PIECE COILING AND AXIAL FIBER DISLOCATION OF EPIDIDYMAL SPERMATOZOA IN T4-TREATED RATS WERE MORE OBVIOUS THAN FOR GOSSYPOL TREATMENT. MITOCHONDRIAL LDH, LDH-X AND MDH WERE ALSO FOUND TO BE INHIBITED BY T4. T4 DID NOT SIGNIFICANTLY AFFECT ENZYME ACTIVITIES IN KIDNEY AND LIVER, THOUGH IT DID CAUSE SLIGHT CHANGES. EFFECTS OF T4 ON THE CHIEF RAT ORGANS WERE MILDER THAN THOSE OF GOSSYPOL, EXCEPT FOR A MORE OBVIOUS ANTIFERTILITY EFFECT. THE AUTHORS SUGGEST THAT T4 MAY BE DEVELOPED INTO AN IDEAL MALE CONTRACEPTIVE. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Gender | MALE |