Experiment 1227061
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | KAUR,P: KHULLAR,M: MITTAL,S: RAI,UC:. (1988). EFFECT OF GOSSYPOL ON TESTES & EPIDIDYMIS OF ALBINO RATS.. 87() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECT OF GOSSYPOL ON MALE GONADS WAS STUDIED IN ALBINO RATS. THE RATS(50) WERE RANDOMLY DIVIDED INTO 4 GROUPS; WHILE GROUP 1 SERVED AS THE CONTROL, 2,3 AND 4 WERE TREATED WITH GOSSYPOL FOR 8 WEEKS. THE TESTES AND EPIDIDYMIS SHOWED CHANGES IN THE GOSSYPOL TREATED ANIMALS. TESTIS SHOWED NECROTIC CHANGE IN SEMINIFEROUS TUBULES IN 42, 75 AND 93 PER CENTS OF RATS IN GROUP 2(20 MG/KG), 75% IN GROUP 3(30MG/KG) AND 93% IN GROUP 4(40 MG/KG), RESPECTIVELY. IN THE EPIDIDYMIS, EVIDENCE OF DEGENERATIVE CHANGES IN EPITHELIAL LINING WAS OBSERVED IN 42, 58 AND 71% OF RATS IN GROUP 2, 3 AND 4 RESPECTIVELY. THE STUDY THUS DEMONSTRATED THAT BESIDES TESTES, EPIDIDYMIS ALSO GETS AFFECTED BY GOSSYPOL TREATMENT. |
| Dose amount | 20-40 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |