Experiment 1227062
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | SINHA KIKIM,AP: HOFFER,AP:. (1987). QUANTITATIVE ANALYSIS OF GERM CELLS AND LEYDIG CELLS IN RAT MADE INFERTILE WITH GOSSYPOL.. 35(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING WAS CARRIED OUT FOR NINE WEEKS WITH THE TITLE COMPOUND. NUMBERS OF A SPERMATOGONIA, PRELEPTOTENE AND PACHYTENE SPERMATOCYTES AND STEP 7 OR 8 SPERMATIDS PER SERTOLI CELL WERE COUNTED IN STAGES VII-VIII OF THE CYCLE OF THE SEMINIFEROUS EPITHELIUM. HIGH DOSES (30 MG/KG) PRODUCED A SIGNIFICANT DROP IN THE RELAVIVE NUMBER OF GERM CELLS COMPARED WITH VEHICLE-TREATED CONTROLS. HOWEVER, NO SIGNIFICANT DEVIATION IN THE RELATIVE NUMBER OF GERM CELLS WAS NOTED BETWEEN CONTROLS AND RATS MADE INFERTILE WITH 10 OR 20 MG/KG/DAY OF GOSSYPOL. STEREOLOGIC TECHNICS WERE USED TO ASSESS THE CNANGES IN THE LEYDIG CELLS. NO SIGNIFICANT DEVIATION IN THE LEYDIG CELL MORPHOLOGY, CELL NUMBERS, OR CELL VOLUME WAS NOTED AS A RESULT OF GOSSYPOL TREATMENT AT THE DOSE LEVELS EMPLOYED. IT APPEARS THAT GERM CELL DEPLETION, SUCH AS THAT CAUSED BY HIGH LEVELS OF GOSSYPOL, IS NOT MEDIATED HBY A CHANGE IN LEYDIG CELL FUNCTION. THE PRESENT REPORT EMPHASIZES THE IMPORTANCE OF STUDIES TO DETERMINE THE MINIMAL EFFECTIVE DOSES FOR GOSSYPOL'S ENTIFERTILITY ACTIVITY IN ANIMAL MODELS AS WELL AS IN MAN. |
| Dose amount | 10-20 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |