Experiment 1227066
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | WANG,JM: QUI,JP: WU,XL: ZHANG,ZR: SHAO,Y: CAO,RQ:. (1988). THE CORRELATION BETWEEN THE GOSSYPOL CONTENTS IN BLOOD PLASMA, RETE TESTIS FLUID, AND CAUDA EPIDIDYMAL FLUID FOLLOWING CHRONIC TREATMENT WITH GOSSYPOL IN RATS.. 9(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | CONCENTRATION OF GOSSYPOL IN BLOOD PLASMA, RETE TESTIS FLUID AND FLUID FROM THE CAUDA EPIDIDYMIDIS WERE MEASURED STIMULTANTEOUSLY BY HPLC IN RATS TREATED WITH THE TITLE COMPOUND DAILY FOR 3 WEEKS. ANTISPERMATOGENIC EFFECTS WERE DEMOSTRATED LOSS OF SPERM MOTILITY IN THE CAUDA EPIDIDYMISIS AND STRUCTURAL CHANGES IN THE TESTIS. CONCENTRATIONS OF GOSSYPOL WERE LOWER IN RETE TESTIS FLUID COMPARED WITH BLOOD PLASMA BUT INCREASED SIGNIFICANTLY IN FLUID FROM THE CAUDA EPIDIDYMISIS. THE RESULTS INDICATE A RESTRICTION OF THE BLOOD-TESTIS BARRIER TO GOSSYPOL AND ITS LOCAL CONCENTRATION ITS LOCAL CONCENTRATION IN THE EPIDIDYMIDIS AFTER FLUID RESORPTION. |
| Dose amount | 15.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |