Experiment 1227070
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Zingiber officinale (ZINGIBERACEAE) |
| Citation | FISCHER-RASMUSSEN,W: KJAER,SK: DAHL,C: ASPING,U:. (1991). GINGER TREATMENT OF HYPEREMESIS GRAVIDARUM.. 38(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIRTY WOMEN PARTICIPATED IN A DOUBLE-BLIND RANDOMIZED CROSSOVER TRIAL OF THE EFFICACY OF POWDERED GINGER ROOT AND PLACEBO IN HYPEREMESIS GRAVIDARUM. THREE PATIENTS HAD TO BE WITHDRAWN. EACH WOMAN SWALLOWED CAPSULES CONTAINING EITHER 250 MG OF GINGER OR LACTOSE FOUR TIMES DAILY DURING THE FIRST FOUR DAYS OF THE TREATMENT PERIOD. INTERRUPTED BY A 2 DAY WASHOUT PERIOD THE ALTERNATIVE MEDICATION WAS GIVEN IN THE SECOND 4-DAY PERIOD. THE SEVERITY AND RELIEF OF SYMPTOMS BEFORE AND AFTER EACH PERIOD WERE EVALUATED BY TWO SCORING SYSTEMS. THE SCORES WERE USED FOR STATISTICAL ANALYSES OF POSSIBLE DIFFERENCES. SUBJECTIVELY ASSESSED, 19 WOMEN (70.4%) STATED PREFERENCE TO THE PERIOD IN WHICH GINGER WAS GIVEN, AS WAS LATER ASSESSED B SCORES A SIGNIFICANTLY GREATER RELIEF OF THE SYMPTOMS WAS FOUND AFTER GINGER TREATMENT COMPARED TO PLACEBO (P=0.035). NO SIDE EFFECTS WERE OBSERVED. THE POSSIBLE MUTAGENIC AND ANTIMUTAGENIC CHARACTERISTICS OF GINGER REPORTED IN A STUDY OF E.COLI HAVE NOT BEEN EVALUATED WITH RESPECT TO ANY SIGNIFICANCE IN HUMANS. POWDERED GINGER ROOT IN DAILY DOSES OF 1.0 GM DURING 4 DAYS WAS BETTER THAN PLACEBO IN DIMINISHING OR ELIMINATING THE SYMPTOMS OF HYPEREMESIS GRAVIDARUM. |
| Dose amount | 250.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN(PREGNANT) |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | ROOT |