Experiment 1227081
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | LIU,GZ: LYLE,KC: CAO,J:. (1987). CLINICAL TRIAL OF GOSSYPOL AS A MALE CONTRACEPTIVE DRUG. PART I. EFFICACY STUDY.. 48(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | ONE HUNDRED AND FIFTY TWO HEALTHY VOLUNTEERS WERE ENROLLED IN THIS STUDY. 75 WERE ON A GOSSYPOL REGIMEN AS THE TREATMENT GROUP AND 77 ON PLACEBOS AS THE CONTROL GROUP. THE GOSSYPOL GROUP RECEIVED 20 MG/DAY FOR 75 DAYS FOLLOWED BY 50 MG PER WEEK FOR AN ADDITIONAL 12 MONTH. THIS WAS A DOUBLE-BLIND, PLACEBO GROUP TRIAL. WIVES OF VOLUNTEERS USED CONTRACEPTIVES FOR 75 DAYS FROM THE START OF THE STUDY. THE DRUG WAS FOUND TO BE AN EFFECTIVE CONTRACEPTIVE AGENT IN MALES. NO ADVERSE EFFECTS WERE SEEN ON LIBIDO OR APPETITE. THERE WAS NO EFFECT ON SERUM POTASSIUM LEVELS IN EITHER THE PLACEBO OR GOSSYPOL GROUPS DURING THE LOADING PHASE BUT THERE WAS A STATISTICALLY SIGNIFICANT DECREASE IN POTASSIUM LEVELS DURING THE MAINTEANCE PHASE. 17 CASES COMPLAINED OF FATIGUE, NO PREGNANCIES OCCURRED BY THE END OF MONTH 12. |
| Dose amount | 50.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | WEEK |
| Dose expression | DOSE |
| Gender | MALE |