Experiment 1227124
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | XU,N: ZHONG,CQ: XU,Y: QIAN,SZ:. (1988). A STUDY ON THE COMBINED USAGE OF GOSSYPOL AND POTASSIUM-SPARING DIURETICS.. 8(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING 6 DAYS A WEEK FOR 8 WEEKS WITH GOSSYPOL ALONE OR IN COMBINATION WITH TRIAMTERENE. GOSSYPOL TREATMENT CAUSED DEATH AND DEFORMATION OF SPERM IN THE CAUDA EPIDIDYMIS, REDUCTION IN SPERM COUNT AND LEVELS OF ATP, ADP & AMP IN SPERM. NO CHANGE IN SERUM LEVELS OF TESTOSTERONE, ALKALINE PHOSPHATASE, ACID PHOSPHATASE, TRIGLYCERIDES, CHOLESTEROL, BILIRUBIN AND UREA NITROGEN WERE SEEN. COMBINED USE OF GOSSYPOL AND TRIAMTERENE DID NOT CHANGE THESE RESULTS. GOSSYPOL SLIGHTLY INCREASED URINARY EXCRETION OF K+ BUT DECREASED THAT OF NA+. ADDITION OF TRIAMTERENE REVERSED THE TREND IN K+ CLEARANCE AND INCREASED NA+ CLEARANCE. |
| Dose amount | 5.0 MG |
| Number | 8 |
| Qualitative result | INACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |