Experiment 1227409
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | MARKMAN,M:. (1991). TAXOL: AN IMPORTANT NEW DRUG IN THE MANAGEMENT OF EPITHELIAL OVARIAN CANCER.. 64(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | PHASE 1 TRIALS USING TAXOL SHOWED THE DOSE LIMITING TOXICITY MOST COMMONLY SEEN IN PATIENTS WAS NEUTROPENIA. ADDITIONAL LESS COMMON TOXICITIES SEEN INCLUDED MUCOSITIS, DYSPHAGIA, DIARRHEA, EMESIS, ALOPECIA, NEUROTOXICITY, CARDIAC ARRYTHMIAS AND HYPERSENSITIVITY REACTIONS. MAXIMALLY TOLERATED DOSES OF TAXOL RANGED FROM 110-225 MG/M2 IN PATIENTS WITH EXTENSIVE TO LIMITED CYTOTOXIC DRUG EXPOSURE RESPECTIVELY. PEAK PLASMA CONCENTRATIONS OF TAXOL RANGED BETWEEN 2.3-8.1 MICROMOLAR WITH DOSES OF 175-390 MG/M2. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |