Experiment 1227573
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | GU,ZP: WANG,YX: SANG,GW: WANG,WC: CHEN,ZX: ZHAO,XJ: SHAO,QX: JIANG,YU:. (1990). RELATIONSHIP BETWEEN HORMONE PROFILES AND THE RESTORATION OF SPERMATOGENESIS IN MEN TREATED WITH GOSSYPOL.. 13(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TITLE COMPOUND WAS ADMINISTERED TO 35 MALES VOLUNTEERS AT A DOSE OF 20 MG ONCE A DAY FOR 52-70 DAYS IN THE LOADING PHASE AND TWICE A WEEK FOR 22 MONTHS IN THE MAINTENANCE PHASE. SPERM COUNTS AND THE SERUM CONCENTRATIONS OF LH, FSH, PROLACTIN, TESTOSTERONE AND ESTRADIOL WERE MONITORED REGULARLY DURING TREATMENT AND FOR A FOLLOW-UP PERIOD OF 12 MONTHS. AT AROUND 90 DAYS AFTER TREATMENT, ALL PARTICIPANTS APPROACHED OR ATTAINED AZOOSPERMIA AND REMAINED AT THIS LEVEL THROUGHOUT THE MAINTENANCE PHASE. BY THE END OF THE FOLLOW-UP PHASE, 8-27 MEN WERE RESTORED TO NORMAL LEVELS. THE ONLY HORMONE THAT CHANGED SIGNIFICANTLY DURING AND AFTER TREATMENT WAS FSH. FROM THE SIXTH MONTH OF THE TREATMENT TO THE END OF THE FOLLOW-UP PHASE, SERUM CONCENTRATIONS OF FSH IN THE 8 PARTICIPANTS THAT REACHED IRREVERSIBLE AZOOSPERMIA WERE SIGNIFICANTLY HIGHER THAN IN THE OTHER 27 MEN OR IN CONTROLS. IT IS SUGGESTED THAT MONITORING OF FSH LEVELS MIGHT BE OF DIAGNOSTIC VALUE FOR IDENTIFYING THOSE PARTICIPANTS WITH IRREVERSIBLE AZOOSPERMIA DURING GOSSYPOL TREATMENT. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |