Experiment 1231952
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | WANG,Y: SUN,YB: CHEN,QQ: LU,CY: ZONG,SD: QIAN,ZJ:. (1993). EFFECT OF TRIPTOLIDE ON REPRODUCTIVE ENDOCRINOLOGY AND DIHYDROTESTOSTERONE RECEPTORS IN RATS.. 2(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 35 DAYS. AFTER 28 DAYS OF TREATMENT, MATING TESTS SHOWED THAT ALL OF THE DRUG-TREATED RATS WERE INFERTILE. AT THE END OF THE DRUG TREATMENT, THE DENSITY OF CAUDAL SPERMATOZOA AND THE WEIGHT OF EPIDIDYMIS WERE REDUCED. ALL THE SPERMATOZOA WERE IMMOBILE. THERE WAS NO DETECTABLE DAMAGE OF TESTICULAR SPERMATOGENESIS AND EPIDIDYMAL EPITHELIA AND TRIPDOLIDE-TREATED RATS. HOWEVER, MODERATE AND SEVERE DAMAGE OF SPERMATOZOA WERE SEEN IN THE CORPUS AND CAUDAL EPIDIDYMIS. THE CONTENTS OF CYTOSOLIC AND NUCLEAR DIHYDROTESTOSTERONE(DHT) RECEPTORS IN THE CAPUT AND CAUDAL EPIDIDYMIDES INCREASED INSIGNIFICANTLY AS COMPARED WITH CONTROLS. HOWEVER, CYTOSOLIC OF DHT RECEPTORS OF THE VENTRAL PROSTATE WERE ELEVATED. THE EPIDIDYMAL SPERM DAMAGE SUGGESTS THAT ONE OF THE SITES OF ACTION OF TRIPTOLIDE MIGHT BE THE EPIDIDYMIS. |
| Dose amount | 75.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |