Experiment 1256923
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | ANON:. (1972). PRELIMINARY INVESTIGATION OF THE ANTIFERTILITY EFFECT OF GOSSYPOL.. 1972() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 4 WEEKS TO MATURE ANIMALS. ANIMALS SACRIFICED ONE AND TWO MONTHS AFTER WITHDRAWAL OF GOSSYPOL. SPERM FROM THE EPIDIDYMIS AND THE TESTIS WERE INVESTIGATED. ONE MONTH AFTER WITHDRAWAL,NO SIGN OF RECOVERY WAS OBSERVED. INSTEAD,THERE WAS AN INCREASED DEGREE OF DAMAGE IN THE TESTIS AND THE EPIDIDYMAL SPERM. TWO TO THREE MONTHS AFTER WITHDRAWAL THERE WAS SLIGHT. RECOVERY IT WAS CONCLUDED THAT SHORT TERM ADMINISTRATION OF GOSSYPOL AFFECTS THE SPERMATIDS AND PRIMARY SPERMATOCYTES,WHILE LONG TERM DOSING AFFECTS THE SPERMATOGONIA. |
| Dose amount | 30.0 MG |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |