Experiment 1257951
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IM |
| Organism | Trichosanthes kirilowii (CUCURBITACEAE) |
| Citation | ZHOU,BN:. (1972). PREPARATION AND APPLICATION OF THE INJECTION FROM TRICHOSANTHES KIRILOWII MAXIM. USED AS AN ABORTIFACIENT AGENT.. 1972(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS SHOWED SIGNS OF DEPRESSION,LOSS OF APPETITE AND REFUSED TO EAT. EFFECTS WERE PROPORTIONAL TO THE DOSE, EFFECTS WERE REVERSIBLE AND ANIMALS RECOVERED WITHIN 2-5 DAYS. THE WBC COUNT WAS 3-4 MILLION AND THE PERCENTAGE OF NEUTROPHILS INCREASED TO 90%. BOTH OF THESE VALUES NORMALIZED ONE WEEK AFTER DOSING. IN THE ECG,THE ST REGION SHOWED TEMPORARY DEPRESSION AND THEN RETURNED TO NORMAL AFTER 2-3 DAYS. ANIMALS DID NOT RECOVER AT HIGHER DOSE LEVELS. OBVIOUS INVERSION OF THE T WAVE WAS OBSERVED. THE NPN LEVEL WAS UNCHANGED AT THIS DOSE LEVEL BUT AT HIGHER DOSES IT INCREASED SHARPLY, AS HIGH AS 200 MG%. AN ACCOMPANYING DECREASE IN LEVELS OF SERUM NA AND CL, AN INCREASED IN SERUM K AND A DECREASE IN THE FORMATION OF CO2 WERE NOTED AT THE SAME TIME THAT METABOLIC ACIDOSIS WAS APPARENT. THERE WAS AN ABVIOUS INCREASE IN SGPT LEVELS IN ANIMALS RECEIVING HIGHER THAN THIS DOSE. AT THE INDICATED DOSE LEVEL, ONLY A SLIGHT INCREASE IN SGPT LEVEL WAS SEEN. HISTOPATHOLOGICAL DATA ARE PRESENTED AND DISCUSSED. |
| Dose amount | 0.2-2 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | DOG |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | H2O EXT |