Experiment 1257955
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IM |
| Organism | Trichosanthes kirilowii (CUCURBITACEAE) |
| Citation | ZHOU,BN:. (1972). PREPARATION AND APPLICATION OF THE INJECTION FROM TRICHOSANTHES KIRILOWII MAXIM. USED AS AN ABORTIFACIENT AGENT.. 1972(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | TOTAL OF 2500 CLINICAL TRIALS WITH THIS MATERIAL HAVE BEEN CONDUCTED IN 40 HOSPITALS IN SHANGHAI AND 30 IN OTHER PARTS OF CHINA. SUITABLE INDICATIONS WERE MID-TERM PREGNANCY, DEAD FETUS, LATE ABORTION, HYDATIDIFORM MOLE, MALIGNANT MOLE AND IMPLANTATION OUTSIDE OF THE UTERUS. THE PERCENTAGE INDUCTION OF LABOR IN MID-TERM PREGNANCIES WAS STATED TO BE 96.4%. A SINGLE INJECTION WAS REQUIRED AND THE AVERAGE TIME FOR INDUCTION OF LABOR WAS 6 DAYS 4 HOURS.(2461 PATIENTS). A TOTAL OF 117 PATIENTS WHO WERE EITHER BEARING A DEAD FETUS OR REQUIRED LATE ABORTION RECEIVED A SINGLE INJECTION. THE PERCENTAGE OF LABOR INDUCTIONS WAS 96%. TIME OF LABOR INDUCTION WAS SHORTER THAN IN MID-TERM ABORTION. ABOUT 71% OF THE PATIENTS REQUIRED LESS THAN 4 DAYS, 19.6% REQUIRED 4-7 DAYS AND 9.4% REQUIRED MORE THAN 7 DAYS. DATA ARE ALSO GIVEN FOR USE OF THE INJECTION FOR HYDATIDIFORM MOLE, INPLANTATIONS OUTSIDE OF THE UTERUS AND MALIGNANT MOLE(IV ADMINISTRATION IN THE LATTER CASES). CAUTION: BECAUSE OF THE ANTIGENIC CHARACTER OF THIS PRODUCT, SKIN TESTS ARE REQUIRED. SIDE EFFECTS AND CONTRAINDICATIONS: IN GENERAL THERE IS AN INCREASE IN BODY TEMPERATURE TO ABOUT 38.5 C WITHIN 48 HOURS AFTER THE DRUG IS ADMINISTERED. COMMON SIDE EFFECTS ARE PAIN IN THE LIMBS,THROAT AND INFECTION AREA AND HEADACHE. THE DRUG IS UNSUITABLE FOR PATIENTS GIVING A POSITIVE SKIN TEST TO TRICHOSANTHIN OR EXTRACT OF TRICHOSANTHES KIUBRLOWII OR TO SUBJECTS WITH MAL FUNCTIONING HEART,LIVER OR KIDNEYS. THE DRUG IS UNSTABLE IN SOLUTION AND MUST BE PROTECTED FROM LIGHT. |
| Dose amount | 0.2 MG |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | HUMAN(PREGNANT) |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | H2O EXT |