Experiment 1258935
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Asclepias tuberosa (ASCLEPIADACEAE) |
| Citation | HASSAN JR,WE: REED,HL:. (1952). STUDIES ON SPECIES OF ASCLEPIAS. 6. TOXICOLOGY, PATHOLOGY, AND PHARMACOLOGY.. 41() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 10 DAYS. AT THE END OF THE 5TH DAY ALL ANIMALS WERE LIVING BUT IN POOR PHYSICAL CONDITION. ALL ANIMALS WERE SUFFERING FROM DIARRHEA AND WERE CONTINUOUSLY IN TREMORS. THEY WOULD NOT TAKE FOOD AND APPEARED TO HAVE GENERAL MUSCULAR PARALYSIS. THE ANIMALS WERE KILLED AND EXAMINED GROSSLY. PETECHIAE WERE NOTED IN THE HEARTS OF 60% OF THE ANIMALS. THE LUNGS IN ALL ANIMALS WERE BLANCHED AND HEMORRHAGIC. THE LIVER APPEARED TO HAVE VERY SMALL PETECHIAE AND THE KIDNEYS OF ALL ANIMALS WERE SWOLLEN. THE GASTROINTESTINAL TRACT WAS BLANCHED, DISTENDED WITH AIR AND HEMOORHAGIC IN ALL ANIMALS. OVARIES, ADRENALS AND PANCREAS APPEARED NORMAL. |
| Dose amount | 10.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | FLUIDEXTRACT |