Experiment 1258949
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Asclepias incarnata (ASCLEPIADACEAE) |
| Citation | HASSAN JR,WE: REED,HL:. (1952). STUDIES ON SPECIES OF ASCLEPIAS. 6. TOXICOLOGY, PATHOLOGY, AND PHARMACOLOGY.. 41() |
| Amount utilized | |
| Compound isolated | |
| Disease | DOSING WAS EQUIVALENT TO 80 MG/KG OF THE DRIED PLANT MATERIAL. SYMPTOMS WERE PARTIAL PARALYSIS WITH EXCESSIVE SALIVATION, A STAGE OF CONVULSIONS FOLLOWED BY OPISTHOTONOS AND EMPROSTHOTONOS, MILD TETANIC SPASMS AND FINALLY DEATH. AUTOPSY RESULTS WERE AS FOLLOWS: SURFACE VESSELS OF THE BRAIN WERE INFLAMED AND CLOTS WERE OBSERVED BETWEEN THE CEREBELLUM AND CEREBRUM. THE HEART WAS IN SYSTOLE AND OFTEN PETECHIAE WERE OBSERVED. LUNGS WERE BLANCHED, HEMORRHAGIC, AND OFTEN COLLAPSED. LIVER APPEARED TO BE NORMAL. KIDNEYS APPEARED CONGESTED. THE GI TRACT WAS BLANCHED AND DISTENDED WITH AIR. THE MESENTERIC ARTERIOLES EXHIBITED A SLIGHT HEMORRHAGE. THE BLADDER WAS USUALLY EMPTY AT AUTOPSY BECAUSE OF THE FACT THAT IT WAS USUALLY EMPTIED DURING THE EARLY CONVULSIVE STATES. BLOOD VESSELS OF THE SPINAL CORD MENINGES WERE DISTENDED WITH BLOOD. EXTRACTS PREPARED FROM THE AERIAL PARTS OF THE PLANT PRODUCED SIMILAR RESULTS. |
| Dose amount | 0.1 ML |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | FLUIDEXTRACT |