Experiment 1262655

Details

PropertyValue
Pharmacology
Administration routeIN RATION
OrganismCrotalaria spectabilis (FABACEAE)
CitationCOX,DH: HARRIS,DL: RICHARD,TA:. (1958). CHEMICAL IDENTIFICATION OF CROTALARIA POISONING IN HORSES.. 133()
Amount utilized
Compound isolated
DiseaseTHREE HORSES IN A HERD DIED DURING 1957 AND ANOTHER DURING 1958,APPARENTLY FROM OLD AGE. THE FIELD THAT THE ANIMALS GRAZED IN CONTAINED THE TITLE PLANT. LATER IN 1958 ANOTHER HORSE BECAME ILL,EXHIBITING EXTREME LISTLESSNESS,WEAKNESS,STUMBLING AND A PROFUSE DIARRHEA. TREATMENT WAS INITIATED BUT THE ANIMAL DIED ABOUT A WEEK LATER. ANOTHER HORSE FROM THE HERD DIED LATE IN MAY AND AT NECROPSY THERE WAS SEVERE CIRRHOSIS OF THE LIVER AND RELATED SIGNS OF LIVER TOXICITY. MONOCROTALINE,THE MAJOR ALKALOID OF THE TITLE PLANT THAT WAS PRESUMED INGESTED BY THE HORSES,WAS FOUND IN THE LIVER OF THE DEAD ANIMAL.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHORSE
Dose expressionCONC USED
ExtractAERIAL PARTS