Experiment 1262755
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Cassia occidentalis (FABACEAE) |
| Citation | O'HARA,PJ: PIERCE,KR:. (1974). TOXIC CARDIOMYOPATHY CAUSED BY CASSIA OCCIDENTALIS. II. BIOCHEMICAL STUDIES IN POISONED RABBITS.. 11(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EXTRACT UNCOUPLED OXIDATIVE PHOSPHORYLATION IN MYOCARDIAL MITOCHONDRIA, THEREBY PREVENTING THE CONVERSION OF ENERGY DERIVED FROM RESPIRATION INTO ATP. SUCH MITOCHONDRIA WERE UNABLE TO MAINTAIN IONIC GRADIENTS AND BECAME SWOLLEN, RESULTING IN FAILURE OF RESPIRATION, DISRUPTION OF MITOCHONDRIAL STRUCTURE AND MYOCARDIAL DEGENERATION. MITOCHONDRIAL DAMAGE WAS EVIDENT IN THE FIRST HEART MUSCLE LESIONS OBSERVABLE IN POISONED ANIMALS. MYOCARDIAL ISOCITRIC DEHYDROGENASE AND LACTIC DEHYDROGENASE ACTIVITIES INCREASE IN THESE ANIMALS, GLYCOGEN WAS DEPLETED AND LACTATE WAS ACCUMULATED. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |