| Disease | THE DOSE INDICATED WAS ADMINISTERED OVER A PERIOD OF 7 HOURS. THE ANIMAL DIED OVERNIGHT ON THE DAY OF DRENCHING.
POST-MORTEM APPEARANCE: SLIGHT POST-MORTEM CHANGES,GENERAL CYANOSIS,SLIGHT HYDROTHORAX,SEVERE HYDROPERICARDIUM,HYPEREMIA OF THE MUCOSA OF THE TRACHEA AND BRONCHI,SEVERE HYPEREMIA,EDEMA AND EMPHYSEMA OF THE LUNGS,
SUBEPICARDIAL PETECHIAE,SLIGHT REGRESSIVE CHANGES IN THE MYOCARDIUM, SEVERE REGRESSIVE CHANGES IN THE LIVER AND KIDNEYS.
OTHER CHANGES INCLUDED HEMORRHAGIC LYMPHADENITIS,SLIGHT HYPEREMIA OF THE MUCOSA OF THE ABOMASUM,SMALL AND LARGE INTESTINES WITH SUB-MUCOSAL HEMORRHAGES IN THE SMALL INTESTINE, STASIS OF THE INGESTA IN THE LARGE INTESTINE.
HISTOLOGY: LIVER: THE SINUSOIDS WERE DISTENDED WITH A LARGE QUANTITY OF BLOOD. THE HEPATIC CELLS SHOWED PARENCHYMATOUS DEGENERATION.
HISTOLOGY: KIDNEY: HYPEREMIA ACCOMPANIED BY HEMORRHAGES WHILE THE PROXIMAL CONVULUTED TUBULES SHOWED SEVERE DEGENERATIVE CHANGES. THE NUCLEI OF THE EPITHELIAL CELLS OF THESE TUBULES SHOWED PYKNOSIS AND KARYOLYSIS.
IT WAS CONCLUDED, AFTER A SECOND SAMPLE WAS TESTED, THAT THE CAUSE OF DEATH WAS DUE TO DIGESTIVE DISTURBANCES FOLLOWING TOO LARGE A DOSE OF THE ROOTS. |